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Busto, U. and Sellers, E.M. (1986) Pharmacokinetic Determinants of Drug Abuse and Dependence: A Conceptual Perspective. Clinical Pharmacokinetics, 11, 144-153.
https://doi.org/10.2165/00003088-198611020-00004

has been cited by the following article:

• TITLE: Successful Outpatient Management of Tizanidine Withdrawal Syndrome: A Case Report

  AUTHORS: Sina Radparvar

  KEYWORDS: Withdrawal Syndrome, α2-Adrenergic Agonists, Tizanidine Withdrawal, Tizanidine Dependence, Adrenergic Effect

  JOURNAL NAME: Case Reports in Clinical Medicine, Vol.15 No.8, August 14, 2026

  ABSTRACT: Tizanidine withdrawal syndrome is an infrequently reported condition caused by the abrupt cessation of tizanidine, a short-acting central α2-adrenergic receptor agonist. This case details a 38-year-old female who presented with moderate withdrawal syndrome induced by the abrupt discontinuation of high-dose tizanidine. The patient presented with autonomic and adrenergic hyperactivity, neuromuscular rebound, and neuropsychiatric disturbances. Management utilized multiple medications targeting hyperadrenergic and autonomic hyperactivity. This was followed by the reintroduction of tizanidine at a lowered baseline dose, which was then gradually reduced using a structured down-taper. The case illustrates an ambulatory detoxification protocol useful for tizanidine withdrawal management.