TITLE:
Low IGSF10 Protein Expression Is Associated with Advanced NSCLC Stage and Histological Heterogeneity
AUTHORS:
Huaxue Xing, Bo Ling, Yun Zhao, Lianyu Cheng, Beibei Ma
KEYWORDS:
Non-Small Cell Lung Cancer, IGSF10, Tissue Microarray, Clinical Stage, Immunohistochemistry
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.14 No.8,
August
13,
2026
ABSTRACT: Objective: To investigate the protein expression profile of immunoglobulin superfamily member 10 (IGSF10) in non-small cell lung cancer (NSCLC) tissues and its association with clinicopathological characteristics. Methods: Tissue samples were collected from 112 patients with pathologically confirmed NSCLC, including 59 cases of lung adenocarcinoma and 53 cases of lung squamous cell carcinoma. Tissue microarrays were constructed using tumor tissues and paired adjacent non-tumor tissues. IGSF10 protein expression was detected by immunohistochemistry and quantified using the H-score system. Statistical analyses were performed to evaluate the associations between IGSF10 expression and T/N/M stage, clinical stage, and histological subtype. Results: IGSF10 expression was significantly higher in adjacent non-tumor tissues than in tumor tissues (p = 0.004). In tumor tissues, IGSF10 expression decreased with tumor progression. The H-scores were lower in patients with T2 - T4 disease, M1 disease, and clinical stage II - IV disease than in those with T1 disease, M0 disease, and clinical stage I disease, respectively. Low IGSF10 expression was also associated with advanced N stage. Histological comparison showed that IGSF10 expression was significantly lower in lung squamous cell carcinoma than in lung adenocarcinoma (p Conclusion: IGSF10 protein expression is downregulated in NSCLC tumor tissues and is associated with T/N/M stage, clinical stage, and the lung squamous cell carcinoma phenotype. These findings suggest that reduced IGSF10 expression may be involved in NSCLC progression and may serve as a candidate histological marker reflecting tumor advancement.