TITLE:
Advances in CT Perfusion Imaging Combined with High-Resolution Vessel Wall MRI for Ischemic Stroke
AUTHORS:
Wenjing Wang, Daokai Gong
KEYWORDS:
Ischemic Stroke, CT Perfusion Imaging, High-Resolution Magnetic Resonance Vessel Wall Imaging, Multimodal Imaging
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.14 No.8,
August
11,
2026
ABSTRACT: CT perfusion imaging (CTP) and high-resolution magnetic resonance vessel wall imaging (HR-VWI) are two important modalities in the imaging assessment of ischemic stroke, providing complementary information from hemodynamic and vessel wall structural perspectives, respectively. CTP enables rapid quantification of the infarct core and ischemic penumbra in the acute phase, supporting decision-making reperfusion therapy, particularly in patients presenting beyond 6 hours from symptom onset. HR-VWI directly visualizes pathological changes of the vessel wall and offers unique advantages in differentiating etiologies such as atherosclerosis, arterial dissection, moyamoya disease and vasculitis. In recent years, the multimodal integration of these two techniques has gained increasing attention; however, related clinical studies remain in early stages, facing challenges including insufficient evidence, lack of technical standardization, and limited generalizability of artificial intelligence models. This review systematically summarizes the technical principles, clinical applications, and limitations of CTP and HR-VWI, with a focus on the current evidence and future directions for their combined use, aiming to inform precision imaging assessment in ischemic stroke.