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Kashiwagura, Y., Uchida, S., Tanaka, S., Watanabe, H., Masuzawa, M., Sasaki, T., et al. (2014) Clinical Efficacy and Pharmacokinetics of Levothyroxine Suppository in Patients with Hypothyroidism. Biological and Pharmaceutical Bulletin, 37, 666-670.
https://doi.org/10.1248/bpb.b13-00998

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• TITLE: Case Series: Myxedema Crisis and Pericardial Effusion

  AUTHORS: Alejandro Castellanos Pinedo, José Correa Guerrero, Andrea Graciano Castro, Hernando David Vargas Sierra, Julia Regina De Voz Muñoz, Hernando Vargas-Uricoechea

  KEYWORDS: Myxedema, Hypothyroidism, Pericardial, Effusion

  JOURNAL NAME: Case Reports in Clinical Medicine, Vol.15 No.8, August 11, 2026

  ABSTRACT: Myxedema coma is a rare but highly lethal endocrine emergency. It usually presents with altered mental status, hypotension, bradycardia, hypothermia, bradypnea, hyporeflexia, hyponatremia, and hypoglycemia, all resulting from a profound deficiency of thyroid hormones. Additionally, affected individuals may present with signs of low cardiac output, generalized edema, shock, pericardial and/or pleural effusion, and altered mental status (with or without coma). We present three cases of patients with myxedema coma and pericardial effusion, all with unusual clinical features.