TITLE:
Profile of Lymphocytic and Granulocytic Activities in Senegalese Patients with Atopic Dermatitis According to Disease Duration
AUTHORS:
Frederic Christian Diaz, Bambi Ngom, Khadim Diop, Mame Téné Ndiaye, Moustapha Mbow, Tandakha Ndiaye Dieye, Maguette Deme Sylla Niang, Alioune Dieye, Oumou S. Niang, Boubacar Ahy Diatta, Babacar Mbengue
KEYWORDS:
Atopic Dermatitis, Lymphocytes, Granulocytes, IgE, FcεRI, Immuno-Allergy
JOURNAL NAME:
Open Journal of Immunology,
Vol.16 No.3,
August
6,
2026
ABSTRACT: Atopic dermatitis is an inflammatory skin disease with a juvenile tendency (15% - 20%) of cases with a chronic component that could justify the prevalence in adults (7%). Thus, eczematous-type lesions characterize it across various ethnic phenotypes. This pathology is well known in Europe, America, and Asia, but in Africa, especially in sub-Saharan Africa, poor data are available about atopic dermatitis immunopathology. In this African context, we proceeded to study the physiopathology of this pathology by evaluating the activation levels of immune cells, more specifically the level of lymphocyte activation and the membrane expression levels of the FcεRI-IgE complex on granulocytic cells. Our study is conducted from a descriptive and analytical case-control perspective over a period of 3 months, from December 2, 2021, to March 2, 2022, at Le Dantec medical center. The study population was diagnosed in the dermatology department by specialists based on the analysis of their clinical symptoms with the United Kingdom Working Party (SCORAD, CLDQI/DLQI); Statistical data were carried out using non-parametric tests with significance relief at p 0 = 0.640; p