TITLE:
Central Regulation of Erectile Function by Dopaminergic D2 Receptors: Experimental Study in Male Rats and Comparison of the Efficacy of Three Sildenafil Citrate Generics
AUTHORS:
Serge Vastien Thierry Gahie, Lociné Bamba, Nemtiah Ouattara, Tiemelé Eugene Atayi, Abdoulaye Bâ
KEYWORDS:
Erectile Dysfunction, Sildenafil Citrate, Dopamine, D2 Receptors, Wistar Rat
JOURNAL NAME:
Journal of Behavioral and Brain Science,
Vol.16 No.7,
July
31,
2026
ABSTRACT: Objective: This study aimed to evaluate the efficacy of three sildenafil citrate generics and to explore the role of dopaminergic D2 receptors in the central regulation of erectile function. Methods: Adult male Wistar rats received different doses of three generics (Boom, Tre-Bon, Luvmax). Measured parameters included number, duration, and latency of erections, locomotion, and suspension. The most effective product was studied in association with bromocriptine (D2 agonist) and sulpiride (D2 antagonist). Two-way ANOVA analyses were performed. Results: All three generics increased the number and duration of erections, with Boom being the most effective. Low doses (5 and 25 mg) were superior to the 50 mg dose. Bromocriptine potentiated the effects of sildenafil, whereas sulpiride inhibited them. Conclusion: The efficacy of sildenafil generics is variable and dose-dependent. D2 receptors play a key role in the central regulation of erection.