TITLE:
Research Progress on the Improvement of Endothelial Cell Function by Tianma Gouteng Decoction via Regulation of the lncRNA OIP5-AS1/miRNA Axis
AUTHORS:
Xutong Zhu, Shiqi Chen, Diwen Shou
KEYWORDS:
Tianma Gouteng Decoction, Gastrodin, Long Non-Coding RNA OIP5-AS1, Endothelial Cells, Cerebrovascular Diseases
JOURNAL NAME:
International Journal of Clinical Medicine,
Vol.17 No.7,
July
30,
2026
ABSTRACT: Objective: To review the potential interaction between Tianma Gouteng Decoction and the long non-coding RNA OIP5-AS1/miRNA axis in endothelial protection. Method: A review of available literature. Results: We found that long non-coding RNA OIP5-AS1 can regulate endothelial function through ceRNA mechanisms, and this regulation is related to inflammation, apoptosis, as well as vascular remodeling. Tianma Gouteng Decoction has anti-inflammatory effect. In fact, it can also protect the vascular system from damage. Also, gastrodin is a core active component. It can modulate long non-coding RNA OIP5-AS1/miRNA axis through pathways like Wnt/β-catenin. But direct molecular evidence remains limited. Conclusion: Our results can suggest a possible “multi-target, non-coding RNA” regulatory network. It is worth noting that we should integrate gene expression intervention with herbal treatment in future studies and this can validate the interaction. Also, this approach can support endothelial protection in the cerebrovascular disease.