TITLE:
Trafficking and Adaptive Intelligence of AMPA Receptors: A Bibliometric and Biochemical Review of Synaptic Plasticity
AUTHORS:
Zirui Liu
KEYWORDS:
AMPA Receptor Trafficking, Synaptic Plasticity, Long-Term Potentiation, Long-Term Depression, Learning and Memory, Bibliometrics
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.14 No.7,
July
30,
2026
ABSTRACT: Synaptic plasticity is the cellular basis of learning, memory and adaptation. Among the regulatory mechanisms of plasticity, trafficking of AMPA receptor subunits (AMPARs) is relatively important, and it determines how many glutamate receptors are located at excitatory synapses and what their function is. AMPAR trafficking is considered to be the biochemical basis of synaptic signaling and cognition and adaptive intelligence in this review. By summarizing the process of NMDAR insertion, lateral diffusion, synaptic anchoring, endocytosis and recycling, as well as phosphorylation and interactions among NMDARs, GluA1/GluA2 subunits, CaMKII, PKA, PKC, PSD-95, PICK1, GRIP and TARPs, it is hoped that the connections between these processes and long-term potentiation and long-term depression, learning and memory, cognitive flexibility and vulnerability to neurological and psychiatric diseases will be explored. A bibliometric module will be built in R with the help of the bibliometric package to analyze the development trends of the data, keyword co-occurrence and theme changes, etc. Finally, this paper also provides cross-disciplinary suggestions for NeuroAI, neuroengineering, brain-computer interfaces, computational neuroscience, psychology, etc. AMPAR trafficking is a molecular model of adaptation, and the cause of behavior is not yet known in terms of receptor dynamics.