TITLE:
Alkalinizing Effect of Sodium Acetate Administered by Ororuminal Route in Adult Cattle
AUTHORS:
Paulo C. A. Amorim, Fabrício L. Valente, Samuel R. Alves, Felipe S. Mattos, Caio M. Costa, Lorena C. Monteiro, Marcel F. B. Avanza, Raffaella B. C. Teixeira, João V. M. Mota, Nathalia S. Rosse, Júlio A. N. Lisbôa, Hélio C. Manso Filho, Elizabeth H. Melo, José D. Ribeiro Filho
KEYWORDS:
Alkalizing, Metabolic Acidosis, Hyperchloremia, Ruminal Fluid
JOURNAL NAME:
Open Journal of Veterinary Medicine,
Vol.16 No.7,
July
28,
2026
ABSTRACT: This study aimed to evaluate the alkalizing potential of sodium acetate administered via ororuminal tubing in adult cattle. Six clinically healthy crossbred cows, with an average age of 5 years and average weight of 500 kg were used in a 6 × 2 crossover design, with seven-day intervals between treatment cycles, and each animal receiving both treatments. The animals were distributed into two treatments as described: TREAT1g: 1 g∙kg−1 of sodium acetate diluted in 5 liters of water administered by ororumenal route; TREAT2g: 2 g∙kg−1 of sodium acetate diluted in 5 liters of water administered by ororumenal route. The physical examination included measuring rectal temperature, heart rate, respiratory rate, and ruminal motility. The following biochemical and hematological parameters were measured: packed cell volume, plasma proteins, serum sodium, potassium, chloride, calcium, magnesium, phosphorus, urea, creatinine, and serum osmolarity; plasma glucose and lactate; and blood gas analysis (pH, pCO2, ctCO2,
HCO
3
−
, and BE). The anion gap and SID3 were calculated, while urine pH, sodium, potassium, chloride, calcium, and magnesium were measured. In animals from the TREAT1g and TREAT2g groups, decreases were recorded in ruminal motility, serum potassium and total calcium, urinary chloride, calcium, and magnesium, while increases were detected in serum and urinary Na+ values, plasma glucose, pH, and osmolarity of ruminal fluid, blood pH,
HCO
3
−
, ctCO2, BE, SID3, and urine pH. Conversely, increases in serum creatinine and osmolarity values were recorded only in animals from the TREAT2g. In conclusion, both treatments caused metabolic alkalosis by strong ions and a slight increase in the pH value of the ruminal fluid.