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O. Yanarates, A. Dogrul, V. Yildirim, A. Sahin, A. Sizlan, M. Seyrek, O. Akgül, O. Kozak, E. Kurt and U. Aypar, “Spinal 5-HT7 Receptors Play an Important Role in the Antinociceptive and Antihyperalgesic Effects of Tramadol and Its Metabolite, O-Desmethyltramadol, via Activation of Descending Serotonergic Pathways,” Anesthesiology, Vol. 112, No. 3, 2010, pp. 696-710. doi:10.1097/ALN.0b013e3181cd7920

has been cited by the following article:

• TITLE: Serotonin Influences the Endogenous Opiate Peptides in the Rat Spinal Cord to Participates in Pain Modulation

  AUTHORS: Yan-Juan Pan, Zhi-Kui Yin, Jun Yang, Ying Zhao, Da-Xin Wang

  KEYWORDS: Serotonin; Endogenous Opiate Peptide; Spinal Cord; Antinociception

  JOURNAL NAME: Open Journal of Anesthesiology, Vol.2 No.2, April 19, 2012

  ABSTRACT: Spinal cord is a necessary pathway that transfers the body nociceptive inputs to the brain. Endogenous opiate peptides have been proven to participate in the nociceptive process at spinal level. It has reported that serotonin (5-HT, 5-hydroxytryptamine) in spinal cord plays a role in pan modulation, which can be blocked by opiate receptor antagonists. The present study was designed to investigate the interaction between 5-HT and endogenous opiate peptides at rat spinal level effecting on pain modulation. The results showed that 1) pain stimulation increased not only leucine-enkephalin (L-Ek), β-endorphin (β-Ep) and dynorphin A1-13 (DynA1-13) concentrations but also 5-HT and 5-hydorxyindoleace acid (5-HIAA, the 5-HT main metabolic product) concentrations in spinal cord significantly; 2) 5-HT could increase L-Ek, β-Ep and DynA1-13 concentrations in spinal cord in a dose-dependent manner, whereas cypotolamine (a 5-HT receptor antagonist) decreased L-Ek, β-Ep and DynA1-13 concentrations in spinal cord. The data suggested that 5-HT antinociceptive role might be involved in the endogenous opiate peptide system through 5-HT receptors at spinal level.