TITLE:
A Rare Case of Intensive Care Admission with Baclofen Toxicity
AUTHORS:
Palak Grover, Pritha Mohanta, Gurleen Kaur, Bipneet Singh
KEYWORDS:
Baclofen, GABA-B, Overdose
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.14 No.7,
July
24,
2026
ABSTRACT: This case describes a 58-year-old female who presented to the emergency department with profound altered mental status following the ingestion of approximately 400 mg of baclofen. Because baclofen is not detected on standard urine drug screens and serum levels are not routinely available, the diagnosis remained elusive until the patient recovered enough to report the ingestion. The patient required intensive care unit admission for supportive care, as she remained somnolent for 48 hours. This report emphasizes that baclofen toxicity should be considered in cases of unexplained altered mental status and warns that severe toxicity can mimic brain death, necessitating caution before making irreversible clinical prognostications.