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Robertson, R.P., Harmon, J., Tran, P.O., Tanaka, Y. and Takahashi, H. (2003) Glucose toxicity in β-cells: Type 2 diabetes, good radi-cal gone bad, and the glutathione connection. Diabetes, 52, 581-587. doi:10.2337/diabetes.52.3.581

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• TITLE: Effect of phlorizin on metabolic abnormalities in Spontaneously Diabetic Torii (SDT) rats

  AUTHORS: Takeshi Ohta, Hisayo Morinaga, Takuji Yamamoto, Takahisa Yamada

  KEYWORDS: Hyperglycemia; Phlorizin; SDT Rat

  JOURNAL NAME: Open Journal of Animal Sciences, Vol.2 No.2, April 19, 2012

  ABSTRACT: The Spontaneously Diabetic Torii (SDT) rat is a novel model for nonobese type 2 diabetes. In this study we investigated the glycolipid metabolic changes with phlorizin-treatment, which inhibits intestinal glucose uptake and renal glucose reabsorption, in male SDT rats. Phlorizin (100 mg/kg, b.i.d., s.c.) was administered for 4 weeks to SDT rats from 20 to 24 weeks of age. As a result, phlorizin reduced the development of hyperglycemia and decreased the hemoglobin A1c (HbA1c) levels. In the liver, phlorizin increased mRNA levels of glucokinase, the enzymes related with the glycogen cascade and the proteins associated with lipid metabolism. In conclusion, chronic administration of phlorizin in SDT rats produced a good glycemic control and an improvement in liver function.