TITLE:
Bacteria Isolates Sensitivity Pattern and Pregnancy Outcome of Preterm Pre-Labour Rupture of Fetal Membranes in Ile-Ife, Nigeria
AUTHORS:
E. Babalola Olajide, T. Adeyemo Adeyemi, T. Adeyemo Abolaji, O. Okunola Temitope, D. Ajiboye Akinyosoye, E. Alajiki Olakunle, O. Ayegbusi Ekundayo, J. Akindojutimi Akinyemi, O. Babalola Roseline, A. Ijarotimi Omotade, Olusegun Fehntola Akintunde, O. Onipede Anthony, O. Orji Ernest, B. Fasubaa Olusol
KEYWORDS:
Preterm Prelabour Rupture of Membranes, Bacterial Isolates, Antibiotic Resistant Pattern
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.16 No.7,
July
8,
2026
ABSTRACT: Background: Preterm prelabour rupture of fetal membranes (PPROM) is a significant cause of perinatal morbidity and mortality. It is the leading cause of preterm deliveries and recent studies have shown that lower genital tract infections are major aetiological factors. Antimicrobial therapy is paramount in the management of PPROM, however, emergence of multidrug-resistant (MDR) pathogens has significantly challenged effective management of these patients. The primary aim of the study is to identify antibiotics resistance pattern of bacterial isolates in cases of PPROM in OAUTHC, Ile-Ife. Methods: This was a hospital-based longitudinal descriptive study which involved 120 pregnant women with preterm prelabour rupture of fetal membranes. Demographic and clinical data were obtained from the patient’s case notes. Samples were taken from the egressed amniotic fluid for microbiological analysis. Data were analyzed using statistical package for social sciences (IBM-SPSS) version 20.0. A p-value of 0.05 was taken as statistically significant. Results: The bacterial isolates were predominantly Staphylococcus aureus (29.8%), Escherichia coli (25.2%) and Klebsiella species (16.1%). Of the 131 bacteria, 73 (55.7%) were MDR showing high resistance to many first-and second-line antibiotics, they however, showed high susceptibility to piperacillin-tazobactam, amikacin and meropenem. Out of the 120 women that were recruited, 23 (19.2%) developed puerperal sepsis which was the cause of mortality recorded (n = 2; 1.7%). Thirty-four (28.6%) of the total 119 babies delivered alive, developed clinical sepsis and 23 (19.3%) were culture positive cases. MDR blood stream infection was responsible for four (40%) of the total neonatal mortality. Conclusion: Most of the organisms cultured in this study were multiple drug resistant Staphylococcus aureus, Escherichia coli, and Klebsiella species of bacteria with great potential to cause maternal and neonatal infections. They are sensitive to piperacillin-tazobactam, amikacin, meropenem, and Cefuroime. This is evidence to support the need for review of antibiotic treatment protocols for management of PPROM.