TITLE:
Research Progress in Nursing Interventions for Isolated Maternal Hypothyroxinemia during Pregnancy
AUTHORS:
Xin Zhou, Lin Li, Xiao Peng, Li Wang
KEYWORDS:
Isolated Maternal Hypothyroxinemia during Pregnancy, Nursing Intervention, Iodine Nutrition, Iron Deficiency
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.14 No.7,
July
2,
2026
ABSTRACT: Isolated maternal hypothyroxinemia (IMH) is a common thyroid dysfunction during pregnancy. Its prevalence varies substantially according to iodine status, diagnostic criteria, and the use of pregnancy-specific reference ranges. IMH is closely associated with iodine imbalance, iron deficiency, advanced maternal age, parity, pre-pregnancy obesity, and other maternal characteristics. It has been linked to an increased risk of adverse pregnancy outcomes, including macrosomia, preterm birth, gestational diabetes mellitus, and hypertensive disorders of pregnancy, and may also affect offspring neurodevelopment. However, the optimal treatment strategy for IMH remains controversial, highlighting the growing importance of nursing interventions in clinical management. This review summarizes recent progress in nursing interventions for IMH, focusing on early screen and identification, health education and lifestyle management, medication-related nursing care, psychological support, postpartum care and follow-up, multidisciplinary collaboration and continuing care, and digital and intelligent nursing approaches. Current nursing strategies have gradually formed an integrated management model centered on nutritional intervention, particularly iodine and iron optimization. Nevertheless, important limitations remain, including inconsistent intervention standards and insufficient individualized care. This review aims to provide a theoretical basis for optimizing nursing protocols and improving maternal and neonatal health outcomes in pregnant women with IMH.