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R. Luoto, T. I. Kinnunen, M. Aittasalo, P. Kolu, J. Raitanen, K. Ojala, K. Mansikkamaki, S. Lamberg, T. Vasankari, T. Komulainen and S. Tulokas, “Primary Prevention of Gestational Diabetes Mellitus and Large-for-Gestational-Age Newborns by Lifestyle Counseling: A ClusterRandomized Controlled Trial,” PLoS Medicine, Vol. 8, No. 5, 2011, p. e1001036. doi:10.1371/journal.pmed.1001036

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• TITLE: Effects of Dietary and Physical Activity Intervention during Pregnancy on Circulating Leptin and Adiponectin Levels

  AUTHORS: Leena Hilakivi-Clarke, Sonia de Assis, Jani Raitanen, Riitta Luoto

  KEYWORDS: Leptin; Adiponectin; Pregnancy; Randomized Trial

  JOURNAL NAME: Food and Nutrition Sciences, Vol.3 No.4, April 18, 2012

  ABSTRACT: Objective: We investigated whether lifestyle intervention during pregnancy modifies pregnancy leptin and adiponectin levels, adipokines and their association with body mass index (BMI). Methods: Of the 126 pregnant nulliparous women recruited, 43 in the intervention and 56 in the control group completed the study. Blood samples were collected on gestation weeks 8 - 10 (baseline) and weeks 36 - 38 (end of the intervention). Statistical analyses included group-based correlations between adipokines, pre-pregnancy BMI and gestational weight gain and covariance analysis including all confounding factors. Results: Pre-pregnancy BMI correlated with baseline (p = 0.023 and p = 0.079) and end leptin levels (p = 0.128 and p