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K. J. Mather, T. Funahashi, Y. Matsuzawa, S. Edelstein, G. A. Bray, S. E. Kahn, J. Crandall, S. Marcovina, B. Goldstein and R. Goldberg, “Adiponectin, Change in Adiponectin, and Progression to Diabetes in the Diabetes Prevention Program,” Diabetes, Vol. 57, No. 4, 2008, pp. 980-986. doi:10.2337/db07-1419

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• TITLE: Effects of Dietary and Physical Activity Intervention during Pregnancy on Circulating Leptin and Adiponectin Levels

  AUTHORS: Leena Hilakivi-Clarke, Sonia de Assis, Jani Raitanen, Riitta Luoto

  KEYWORDS: Leptin; Adiponectin; Pregnancy; Randomized Trial

  JOURNAL NAME: Food and Nutrition Sciences, Vol.3 No.4, April 18, 2012

  ABSTRACT: Objective: We investigated whether lifestyle intervention during pregnancy modifies pregnancy leptin and adiponectin levels, adipokines and their association with body mass index (BMI). Methods: Of the 126 pregnant nulliparous women recruited, 43 in the intervention and 56 in the control group completed the study. Blood samples were collected on gestation weeks 8 - 10 (baseline) and weeks 36 - 38 (end of the intervention). Statistical analyses included group-based correlations between adipokines, pre-pregnancy BMI and gestational weight gain and covariance analysis including all confounding factors. Results: Pre-pregnancy BMI correlated with baseline (p = 0.023 and p = 0.079) and end leptin levels (p = 0.128 and p