TITLE:
Effects of Dietary and Physical Activity Intervention during Pregnancy on Circulating Leptin and Adiponectin Levels
AUTHORS:
Leena Hilakivi-Clarke, Sonia de Assis, Jani Raitanen, Riitta Luoto
KEYWORDS:
Leptin; Adiponectin; Pregnancy; Randomized Trial
JOURNAL NAME:
Food and Nutrition Sciences,
Vol.3 No.4,
April
18,
2012
ABSTRACT: Objective: We investigated whether lifestyle intervention during pregnancy modifies pregnancy leptin and adiponectin levels, adipokines and their association with body mass index (BMI). Methods: Of the 126 pregnant nulliparous women recruited, 43 in the intervention and 56 in the control group completed the study. Blood samples were collected on gestation weeks 8 - 10 (baseline) and weeks 36 - 38 (end of the intervention). Statistical analyses included group-based correlations between adipokines, pre-pregnancy BMI and gestational weight gain and covariance analysis including all confounding factors. Results: Pre-pregnancy BMI correlated with baseline (p = 0.023 and p = 0.079) and end leptin levels (p = 0.128 and p