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Luo, L., Lin, S., Hu, G., Wu, J., Hu, Y., Nong, F., et al. (2024) Molecular Mechanism of Rolupram Reducing Neuroinflammation in Noise Induced Tinnitus Mice through TLR4/NF kB/NLRP3 Protein/Caspase-1/IL-1 β Signaling Pathway. International Journal of Biological Macromolecules, 278, Article 134987.
https://doi.org/10.1016/j.ijbiomac.2024.134987

has been cited by the following article:

• TITLE: Progress in Neuroinflammation Mechanisms and Targeted Therapy of Tinnitus

  AUTHORS: Guoli Hu, Yewen Huang, Jiahui Wu, Jin Liu

  KEYWORDS: Tinnitus, Neuroinflammation, Neural Remodeling, Signaling Pathway, Anti-Inflammatory Therapy

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.14 No.6, June 25, 2026

  ABSTRACT: Tinnitus is a common auditory perception disorder, and its pathological mechanisms have not been fully elucidated. In recent years, neuroinflammation has garnered widespread attention as a new direction in the study of central mechanisms of tinnitus. This review systematically summarizes the roles of microglia and astrocytes, the TLR4/NF-κB/NLRP3 signaling axis, pro-inflammatory cytokines, and crosstalk between oxidative stress and inflammation in tinnitus. We highlight how neuroinflammation drives auditory central plasticity and remodeling, and discuss recent advances in anti-neuroinflammatory clinical interventions. Studies have shown that neuroinflammation plays a key role in the initiation and maintenance of tinnitus by affecting the neural plasticity of the auditory pathway and limbic system. Targeting neuroinflammation may provide new strategies for tinnitus treatment.