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Shulman, A., Wang, W., Luo, H., Bao, S., Searchfield, G. and Zhang, J. (2021) Neuroinflammation and Tinnitus. In: Searchfield, G.D. and Zhang, J., Eds., Current Topics in Behavioral Neurosciences, Springer International Publishing, 161-174.
https://doi.org/10.1007/7854_2021_238

has been cited by the following article:

• TITLE: Progress in Neuroinflammation Mechanisms and Targeted Therapy of Tinnitus

  AUTHORS: Guoli Hu, Yewen Huang, Jiahui Wu, Jin Liu

  KEYWORDS: Tinnitus, Neuroinflammation, Neural Remodeling, Signaling Pathway, Anti-Inflammatory Therapy

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.14 No.6, June 25, 2026

  ABSTRACT: Tinnitus is a common auditory perception disorder, and its pathological mechanisms have not been fully elucidated. In recent years, neuroinflammation has garnered widespread attention as a new direction in the study of central mechanisms of tinnitus. This review systematically summarizes the roles of microglia and astrocytes, the TLR4/NF-κB/NLRP3 signaling axis, pro-inflammatory cytokines, and crosstalk between oxidative stress and inflammation in tinnitus. We highlight how neuroinflammation drives auditory central plasticity and remodeling, and discuss recent advances in anti-neuroinflammatory clinical interventions. Studies have shown that neuroinflammation plays a key role in the initiation and maintenance of tinnitus by affecting the neural plasticity of the auditory pathway and limbic system. Targeting neuroinflammation may provide new strategies for tinnitus treatment.