TITLE:
Association between Dietary Inflammatory Index and Oxidative Balance Score with Cardiovascular-Kidney-Metabolic Syndrome in US Adults
AUTHORS:
Tong Wang, Lin Li
KEYWORDS:
Dietary Inflammation Index, Dietary Oxidative Balance Score, Dietary Intervention, Cardiovascular-Kidney-Metabolic Syndrome, NHANES
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.14 No.6,
June
25,
2026
ABSTRACT: Background: Inflammation and oxidative stress are key factors in the development of chronic diseases. Diet, a major determinant of these processes, has gained significant attention. This study evaluates the relationship between the Dietary Inflammation Index (DII) and the Dietary Oxidative Balance Score (DOBS) with Cardiovascular-Kidney-Metabolic (CKM) Syndrome. Methods: Using database from the National Health and Nutrition Examination Survey (NHANES) 1999-2018, dietary data were meticulously gathered through two 24-h recall assessments to ascertain the DOBS and DII. Multivariate weighted logistic regression, coupled with restricted cubic spline methodologies, were employed to evaluate the correlations between DOBS, DII, and CKM Syndrome. Subgroup analyses and interaction tests examined effects across genders, ages, races, BMI, smoking, and alcohol consumption. Results: After adjusting for covariates, elevated DOBS concentrations were markedly correlated with a lower prevalence of CKM Syndrome [Q4: OR = 0.49 (0.35, 0.69)], While elevated DII levels were markedly correlated with a higher odds [Q4: OR = 1.62 (1.14, 2.29)]. Restricted cubic splines showed linear negative and positive correlations for DOBS and DII, respectively. Subgroup analyses revealed that DOBS’s protective effect was stronger in females, Whites, and individuals with BMI Conclusion: Higher DOBS is associated with significantly lower odds, and higher DII with higher odds, of having CKM Syndrome. These findings underscore the position of dietary antioxidants and anti-inflammatory components in preventing multisystem diseases, suggesting that dietary improvements may effectively lower odds of CKM syndrome. This research supports public health policies and clinical interventions and provides directions for future studies.