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Mesquita, A., Cardenal-Muñoz, E., Dominguez, E., Muñoz-Braceras, S., Nuñez-Corcuera, B., Phillips, B.A., et al. (2017) Autophagy in Dictyostelium: Mechanisms, Regulation and Disease in a Simple Biomedical Model. Autophagy, 13, 24-40.
https://doi.org/10.1080/15548627.2016.1226737

has been cited by the following article:

• TITLE: Dictyostelium: A Nucleotide Regulated Life-Cycle of Relevance to the Human Condition

  AUTHORS: Wynford Robert Williams

  KEYWORDS: Dictyostelium, Life-Cycle, Purine Nucleotides, Molecular Similarity

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.14 No.6, June 25, 2026

  ABSTRACT: Aspects of Dictyostelium cell biochemistry are sufficient to provide a model for investigating deficiencies in human cell function, of relevance to neurological disorders, mitochondrial syndromes and cancers. Some rapid drug toxicity tests are also based on a Dictyostelium model. Nucleotide modulation is of critical importance in each life-cycle stage of Dictyostelium. In Dictyostelium cells, nucleotide modulators include exclusive eukaryotic compounds, cytokinins, mammalian vasoactive amines and steroids. Many of these modulator compounds do not appear to resemble nucleotide molecular structure. Computational software is used in this study to explore molecular similarity within the molecular structures of nucleotides and compounds demonstrated to influence Dictyostelium development. Results reveal how a disparate range of compounds in the above chemical groups has evolved to modulate the nucleotide chemistry and life-cycle stages of Dictyostelium.