TITLE:
Predictors of Composite Clinical Improvement in Heart Failure with Reduced Ejection Fraction: A Retrospective Cohort Study from Bangladesh
AUTHORS:
Mohammad Ashiqul Haque, Samsun Nahar, N. A. M. Momenuzzaman, Shuvodip Chandra, Md Helal Uddin, Sheikh Fahim Shahriar, Sayema Afroz Eva, Faroque Md Mohsin, Reazur Rahman
KEYWORDS:
Heart Failure with Reduced Ejection Fraction, Bangladesh, Composite Clinical Improvement, NT-proBNP, Lasso Regression, Guideline-Directed Medical Therapy
JOURNAL NAME:
World Journal of Cardiovascular Diseases,
Vol.16 No.6,
June
22,
2026
ABSTRACT: Background: Heart failure with reduced ejection fraction (HFrEF) is a major global health challenge, with an increasing burden in low- and middle-income countries despite advances in therapy. Evidence regarding predictors of therapeutic recovery in Bangladeshi populations remains limited. This study aimed to identify independent baseline predictors of composite clinical improvement (CCI) in a large Bangladeshi cohort with HFrEF. Methods: We conducted a retrospective observational cohort study of 1075 adult patients with HFrEF (LVEF Results: Among 1075 patients (mean age 58.0 ± 25.1 years; 14.2% female), 503 (46.8%) achieved CCI. Multivariable analysis demonstrated that younger age (odd ratio; OR = 0.91 per 10-year increase, p 2 increase, p Conclusions: Our findings support the real-world associations between contemporary HFrEF therapies, including ARNI and SGLT2 inhibitors, and improved clinical outcomes in resource-limited settings. Future prospective research is required to confirm these benefits while accounting for confounding by indication inherent in observational registry data.