TITLE:
FAST-Forward Hypofractionated Radiotherapy in Mucinous Breast Carcinoma: A Case Report
AUTHORS:
Khouloud Ziani, Soukaina Morchid, Imane El Kachtouhi Aarim, Sanae Chaib, Jihane Kharmoum, Mariame Chraibi, Wafaa Merssetti, Nabila Sellal
KEYWORDS:
Mucinous Breast Carcinoma, Hypofractionated Radiation Therapy, FAST-Forward, Elderly Patient
JOURNAL NAME:
Open Access Library Journal,
Vol.13 No.6,
June
18,
2026
ABSTRACT: Mucinous breast carcinoma is a rare malignant tumor (1% - 4% of breast cancers), generally associated with a favorable prognosis. Its management is multidisciplinary; adjuvant radiation therapy aims to reduce the risk of locoregional recurrence. Short hypofractionated regimens, including the FAST-Forward protocol, are increasingly used in older patients due to their convenience and demonstrated efficacy in standard series of ductal carcinoma. We report the case of an 86-year-old female patient with mucinous carcinoma of the left breast classified as cT3N0M0; treated with surgery, hormone therapy, and adjuvant radiotherapy according to the FAST-Forward regimen (26 Gy in 5 fractions over one week), using a three-dimensional technique that allows for optimal coverage without exceeding the dose limits for at-risk organs. The treatment was well tolerated, and the patient did not experience any acute or late radiation-induced toxicity. After 15 months of follow-up, no locoregional recurrence was observed, and functional quality of life was preserved. This case demonstrates that the hypofractionated FAST-Forward regimen may be a safe and practical option for the adjuvant management of mucinous breast carcinoma in elderly patients. Larger series and long-term follow-up are needed to confirm the safety and efficacy specific to this histological subtype.