TITLE:
IgG4-Related Disease Presenting with Jaundice: A Case Report from Senegal
AUTHORS:
Marième Polèle Fall, Salamata Diallo, Mamadou Ngoné Gueye, Alia Issa, Alioune Badara Fall, Marie Louise Basséne, Daouda Dia
KEYWORDS:
IgG4-Related Disease, Autoimmune Pancreatitis, Sclerosing Cholangitis, Nephritis
JOURNAL NAME:
Case Reports in Clinical Medicine,
Vol.15 No.5,
May
18,
2026
ABSTRACT: Introduction: IgG4-related disease is a recently recognized fibroinflammatory condition that can involve multiple organs. We report a case with pancreatic, biliary, and renal involvement. Observation: This was a 38-year-old patient presenting with jaundice associated with generalized pruritus and weight loss. He had a history of allergic rhinitis. Physical examination revealed jaundice and excoriations. Laboratory tests showed cholestasis and cytolysis. The serum IgG4 level was 3.63 g/L. Abdominal computed tomography (CT) and MR cholangiopancreatography demonstrated features consistent with autoimmune disease with pancreatic, biliary, and renal involvement. The clinical course was favorable under long-term corticosteroid therapy. Conclusion: IgG4-related disease is rare but probably underdiagnosed in Africa. It often has a favorable course with appropriately administered corticosteroid therapy.