TITLE:
Association between MEN1 and Medullary Thyroid Carcinoma: Myth or Reality?
AUTHORS:
Hajar Srifi, Malak Riznat, Malad Mohamed, Jad Issouani, Ahmed Anas Guerboub
KEYWORDS:
Multiple Endocrine Neoplasia Type 1, Thyroid Cancer, Papillary Thyroid Carcinoma, Case Report
JOURNAL NAME:
Open Journal of Endocrine and Metabolic Diseases,
Vol.16 No.5,
May
11,
2026
ABSTRACT: Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant genetic disorder characterized by the association of parathyroid, pituitary, and gastroenteropancreatic neuroendocrine tumors. Medullary thyroid carcinoma, on the other hand, is the major manifestation of MEN2. The coexistence of MEN1 and medullary thyroid carcinoma is exceptional and controversial. This review aims to analyze the available data and clarify the possible existence of a pathophysiological link.