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Ong, C.J., Zhao, J.J., Liu, Y., Srivastava, S., Chia, D.K.A., Quek, Y.E., et al. (2025) Spatial Heterogeneity, Stromal Phenotypes, and Therapeutic Vulnerabilities in Colorectal Cancer Peritoneal Metastasis. Clinical Cancer Research, 31, 2515-2529.
https://doi.org/10.1158/1078-0432.ccr-24-3780

has been cited by the following article:

• TITLE: Beyond TNM Staging: Clinical Significance of Combined Molecular Biomarkers (TP53, Ki67, RAS, and MSI) in Colorectal Cancer

  AUTHORS: Taiyan Zhu

  KEYWORDS: Colorectal Cancer, Precision Medicine, TP53, KRAS, Microsatellite Instability, Ki67, Risk Stratification

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.14 No.5, May 7, 2026

  ABSTRACT: Current colorectal cancer management relies on TNM staging and single-gene testing, often failing to capture biological heterogeneity. This study evaluates the synergistic prognostic value of TP53, Ki67, RAS, and MSI in a 120-patient cohort. We identify a high-risk “Triple Hit” phenotype (MSS/RAS-mut/TP53-mut/High-Ki67) that independently predicts poor overall survival, particularly demonstrating significant risk stratification within early-stage disease. Our proposed Combined Molecular Score offers superior prognostic resolution compared to TNM staging alone. This accessible multi-dimensional atlas provides a robust tool for risk assessment, bridging the gap between molecular biology and routine clinical practice while providing a hypothesis-generating framework for future therapeutic intensification.