TITLE:
Beyond TNM Staging: Clinical Significance of Combined Molecular Biomarkers (TP53, Ki67, RAS, and MSI) in Colorectal Cancer
AUTHORS:
Taiyan Zhu
KEYWORDS:
Colorectal Cancer, Precision Medicine, TP53, KRAS, Microsatellite Instability, Ki67, Risk Stratification
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.14 No.5,
May
7,
2026
ABSTRACT: Current colorectal cancer management relies on TNM staging and single-gene testing, often failing to capture biological heterogeneity. This study evaluates the synergistic prognostic value of TP53, Ki67, RAS, and MSI in a 120-patient cohort. We identify a high-risk “Triple Hit” phenotype (MSS/RAS-mut/TP53-mut/High-Ki67) that independently predicts poor overall survival, particularly demonstrating significant risk stratification within early-stage disease. Our proposed Combined Molecular Score offers superior prognostic resolution compared to TNM staging alone. This accessible multi-dimensional atlas provides a robust tool for risk assessment, bridging the gap between molecular biology and routine clinical practice while providing a hypothesis-generating framework for future therapeutic intensification.