TITLE:
Application of Phase Analysis Technology in CZT-SPECT Myocardial Perfusion Imaging in the Field of Cardiovascular Diseases
AUTHORS:
Yuanmei Liu, Juan Meng, Jinbao Huang
KEYWORDS:
CZT-SPECT, Myocardial Perfusion Imaging, Phase Analysis, Mechanical Synchrony, Cardiovascular Conditions
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.14 No.5,
May
7,
2026
ABSTRACT: The advent of cadmium-zinc-telluride semiconductor single-photon emission computed tomography (CZT-SPECT) marks a major technological breakthrough in the field of nuclear cardiology. Based on traditional imaging of myocardial perfusion (MPI), the derived phase assessment technology has realized a leap from static blood flow assessment to dynamic evaluation of myocardial mechanical contraction synchrony. As a core analytical technology of gated myocardial perfusion imaging (GMPI), phase analysis generates phase maps, amplitude maps, phase cine loops, and phase histograms through reconstruction to quantitatively assess left ventricular mechanical contraction synchrony. With the continuous advancement of CZT-SPECT, acquisition protocols, image reconstruction algorithms, and artificial intelligence technologies, the application scope of phase analysis in the precision diagnosis and treatment of cardiovascular diseases continues to expand. This article systematically reviews the technical principles of CZT-SPECT phase analysis, its clinical applications in various cardiovascular diseases, the current challenges, and future development directions, intending to serve as a thorough reference for clinical application and academic research.