TITLE:
Research Progress of PI3K/Akt Signaling Pathway in Polycystic Ovary Syndrome
AUTHORS:
Lining Li, Xiao Qin
KEYWORDS:
Polycystic Ovary Syndrome, PI3K/Akt Signaling Pathway, Pathogenesis
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.14 No.4,
April
30,
2026
ABSTRACT: Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disease driven by multiple factors, which seriously affects female reproduction and metabolic homeostasis. With the deepening of molecular mechanism research, phosphatidylinositol 3-kinase/Protein Kinase B (PI3K/Akt) signaling pathway has gradually become a key entry point to understand the pathogenesis of PCOS. Existing studies have shown that the signaling pathway is deeply involved in the pathological process of PCOS by regulating inflammatory response, oxidative stress, proliferation, apoptosis and autophagy of ovarian granulosa cells. At the same time, the changes of its activity are closely related to the core pathological features such as hyperandrogenism, lipid metabolism disorders and insulin resistance. This article systematically reviews the multiple regulatory effects of PI3K/Akt signaling pathway in the pathogenesis of PCOS, in order to provide a new perspective and intervention targets for disease research.