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Zurcher, C., Van Zwieten, M.J., Solleveld, H.A. and Hollander, C.F. (1982) Ageing research. In. Foster H. L., Small, J.D. and Fox, J.G. Eds., The Mouse in Biomedical Research, Academic Press, New York, 4, 11-35.

has been cited by the following article:

• TITLE: Aging and the decline in health

  AUTHORS: Robin Holliday

  KEYWORDS: Aging; Senescence; Disease; Pathologies; Evolution

  JOURNAL NAME: Health, Vol.2 No.6, June 30, 2010

  ABSTRACT: The biological reasons for aging are now understood. Aging is the result of multiple stochastic events in molecules, cells, tissues and organs. These together produce the aged phenotype, senescence and ultimately death. Many of these changes can be directly linked to specific age-associated disease. However, there are also age-related changes that are not pathological. It can be said that aging has multiple causes, or is instead due to a general loss of molecular fidelity, that is, an increase in disorder. The complexity of organism means that they develop as ordered structures by obtaining energy from the environment. These ordered structures must be maintained by a wide variety of mechanisms which also depend on energy resources. Eventually these mechanisms fail, and senescence sets in. It is known that the efficiency of maintenance is correlated directly with the lifespan of different mammalian species. Also, these lifespans are inversely correlated with fecundity or reproductive potential. There is a trade off between investment of resources in maintenance of the body, or soma, and investment in reproduction.