TITLE:
Innovative and Integrated Strategies for Tuberculosis Diagnosis in Developing Countries
AUTHORS:
Clotaire Donatien Rafaï, Gilles Stéphane Landry Ngaya, Alain Farra, Sitraka Stella Andrimamonjisoa, Boniface Koffi
KEYWORDS:
Strategies, Tuberculosis, Diagnosis, Developing Countries
JOURNAL NAME:
Journal of Tuberculosis Research,
Vol.14 No.2,
April
29,
2026
ABSTRACT: Tuberculosis remains one of the leading causes of death from infectious disease worldwide. In 2023, it affected approximately 10.8 million people and caused 1.25 million deaths, with most cases concentrated in low- and middle-income countries, particularly in Africa and Asia. Despite notable advances in diagnosis over the past two decades, particularly with the introduction of rapid molecular tests, current strategies are reaching their limits in these settings due to fragile health systems, financial constraints, a lack of skilled human resources, and difficulties in maintaining equipment. This review critically analyzes the limitations of conventional and molecular tuberculosis diagnostic strategies in developing countries and explores emerging innovations, including biomarkers, point-of-care testing, artificial intelligence, assisted imaging, and community based approaches. Drawing on field experience in Africa and recent developments in diagnostic tools, we propose an integrated and sustainable strategy combining technological and organizational innovations, adapted to the realities of low-resource countries, to improve early detection, diagnostic confirmation, and management of tuberculosis patients.