TITLE:
Antidiabetic Activity of Sida linifolia Juss. ex Cav. (Malvaceae) and Uvaria chamae P. Beauv. (Annonaceae) Fractions Using ex Vivo Methods
AUTHORS:
Sabrina C. J. Sanvee, Yendubé T. Kantati, Mawupé Claver Ayite, Essotolom Badjabaissi, Mindede Assih, Dermane Affo, Aboudoulatif Diallo, Batomayena Bakoma
KEYWORDS:
Plants, Fractionation, Glucose Transportation, Antioxidant, Rats
JOURNAL NAME:
Open Journal of Medicinal Chemistry,
Vol.16 No.2,
April
28,
2026
ABSTRACT: Background: Diabetes is a disease characterized by chronic hyperglycemia with acute and chronic complications. We have previously reported that the hydroalcoholic extract of Uvaria chamae leaves and of the whole plant of Sida linifolia exerted antihyperglycemic activity in vitro on glucose uptake using yeast cells and ex vivo on glucose absorption by Wistar rats’ muscle and intestine. Objectives: The present study aimed to evaluate the antidiabetic and antioxidant activities of Uvaria chamae and Sida linifolia extracts fractions. Methods: For fractionation, solvents of increasing polarity (n-hexane, chloroform, ethyl acetate, butanol, and distilled water) were used. Also, an evaluation of the in vitro antioxidant activity (DPPH, FRAP) and the ex vivo effect on glucose absorption by Wistar rat muscle and jejunum was performed. Results: Aqueous fractions of Uvaria chamae (0.2 mg/mL) and Sida linifolia (0.1 mg/mL) exhibited the strongest antihyperglycemic activities (P in vitro antioxidant activities. Conclusion: Based on the results found in ex vivo antidiabetic experiments, the fractions of Uvaria chamae and Sida linifolia can be used in further investigations as such as antidiabetic properties assessments using in vivo methods.