TITLE:
Tumor Recurrence Targeting in Active Soft Matter
AUTHORS:
Stefan Z. Stefanov, Irina Trifonova
KEYWORDS:
Targeting, Active Soft Matter, Tumor Recurrence, Temperature-Triggered Drug Release
JOURNAL NAME:
Open Journal of Biophysics,
Vol.16 No.2,
April
23,
2026
ABSTRACT: In this paper, tumor recurrence targeting in active soft matter is developed via temperature-triggered drug release. This is done through probing and retrieving knowledge for heat in the considered soft matter, distinguishing the microenvironment from the tumor in it, and generating the energy current from the microenvironment into the tumor. Tumor targeting intensity and stability are found. Dose scheduling is set for this targeting: dose timing with three dosing moments, which are the moments of typical time and dose modulation, depending on tumor targeting intensity. This dose scheduling is valid at stable tumor targeting. Therapy schemes are simulated for 21 patients with breast cancer.