TITLE:
Research Progress of Biological Scaffold Materials in Pelvic Organ Prolapse
AUTHORS:
Fengqing Wei, Qiwen Pan, Yanli Huang, Xiangyuan Chen, Senjiao Wang
KEYWORDS:
Biological Scaffold, Pelvic Organ Prolapse, Biomaterial
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.14 No.4,
April
15,
2026
ABSTRACT: Pelvic organ prolapse (POP) is a common condition that affects women’s quality of life. Traditional surgical and non-surgical treatments face challenges such as limited efficacy, high reoperation rates, and numerous complications, making it difficult to meet clinical demands. In recent years, the rapid development of tissue engineering technology has provided new directions for POP treatment. Among these, biomaterial scaffolds have become a research hotspot in this field due to their unique potential in supporting pelvic floor tissue regeneration and repairing pelvic floor support structures. This article reviews the core characteristics that ideal biomaterial scaffolds for POP repair should possess. On this basis, it categorizes and provides an in-depth discussion of the main scaffold materials currently applied in clinical practice and research, including natural biomaterials, synthetic polymer materials, and natural-synthetic composite materials. It is worth noting that, at present, the vast majority of novel scaffold materials are still in the preclinical research or early clinical trial stages, while in clinical practice, non-degradable synthetic meshes such as polypropylene (PP) remain the predominant option. This article aims to provide a reference for future research and clinical translation in this field.