TITLE:
Factors Associated with Adverse Fetal Outcomes in Severe Preeclampsia Complicated by Acute Kidney Injury: An Observational Study at Bogodogo University Hospital, Burkina Faso
AUTHORS:
Boukare Ouedraogo, Hamidou Sawadogo, Phillibert Ouedraogo, Jean De La Croix Millogo, Bewendin Evelyne Savadogo/Komboigo, Adama Ouattara, Der Adolphe Some
KEYWORDS:
Fetal Outcome, Preeclampsia, Acute Kidney Injury
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.16 No.4,
April
9,
2026
ABSTRACT: Introduction: Acute kidney injury (AKI) during severe preeclampsia represents a major public health problem. It is associated with high perinatal morbidity and mortality. Several factors, when present, may influence perinatal outcomes. The objective of this study was to describe the factors associated with adverse fetal outcomes in acute kidney injury during severe preeclampsia. Methods: The study was conducted in Burkina Faso at the University Hospital Center of Bogodogo. It was a descriptive-analytical study carried out from September 1, 2023, to August 31, 2024. Exhaustive sampling was used. Univariate analysis was performed using the Chi-square test, followed by multivariate logistic regression to identify factors associated with adverse fetal outcomes. A significance level of Results: A total of 72 cases of AKI during severe preeclampsia were collected. The age group of 18 - 34 years was the most represented. Regarding adverse fetal outcomes, 27 perinatal deaths were recorded, representing 37.5%. Gestational age below 35 weeks significantly increased the risk of perinatal death by more than 19-fold (adjusted OR = 19.5; 95% CI: 3.81 - 40.12; P = 0.001). A systolic blood pressure between 160 and 180 mmHg reduced the risk of perinatal death by 88% (adjusted OR = 0.12; 95% CI: 0.01 - 0.80). Conclusion: This study highlights the high frequency of adverse perinatal outcomes in preeclampsia complicated by acute kidney injury. Prematurity was significantly associated with perinatal death, whereas a systolic blood pressure between 160 and 180 mmHg appeared to be a protective factor.