TITLE:
Effect and Tolerability of a Nutraceutical Supplement Based on Synergic Effect of Plants, Vitamins and Mineral for the Maintenance of Normal Cholesterol Levels: A Multicentric, Observational, Case Series
AUTHORS:
Paola Baggiani, Antonio Di Leo, Manuela Langella, Alessandro Sabatini, Riccardo Tomassini
KEYWORDS:
Total Cholesterol, IMOpro Cholequil®, Synergic Effects, Plants, Vitamins, Minerals
JOURNAL NAME:
Open Journal of Gastroenterology,
Vol.16 No.4,
April
2,
2026
ABSTRACT: Background: Hypercholesterolemia remains a major risk factor for cardiovascular disease, which continues to represent one of the leading causes of mortality worldwide. Although statins are the first-line pharmacological therapy, nutraceutical formulations containing plant extracts combined with vitamins and minerals are increasingly used as complementary strategies for lipid profile modulation. This case series investigates the effects of the nutraceutical supplement IMOpro Cholequil® on cholesterol modulation in a small cohort of patients. Methods: This case series included 8 adults (four men, four women; age range 38 - 82 years) with abnormal total cholesterol levels at baseline (day 0) who presented to a pharmacy or their primary care physician. All subjects were recommended one nutraceutical supplement tablet once a day for a period of 90 days. Total cholesterol, HDL, and LDL levels were assessed at baseline, day 30, and day 90. Results: All patients showed a clinically relevant improvement in total cholesterol levels after 30 and 90 days of nutraceutical supplementation. Conclusion: Supplementation with a nutraceutical formulation containing synergistic plant extracts, vitamins, and minerals was associated with normalization or improvement of total cholesterol, LDL cholesterol, and triglyceride levels. Larger controlled studies are warranted to confirm these findings.