TITLE:
Lipid-Lowering Effect of Red Glutinous Sorghum in High-Fat Diet-Induced Obese Mice
AUTHORS:
Yanlin Qin, Ren Zou, Qiming Yu
KEYWORDS:
Red Glutinous Sorghum, High-Fat Diet, Obesity, Lipid-Lowering Effect
JOURNAL NAME:
Open Access Library Journal,
Vol.13 No.4,
April
1,
2026
ABSTRACT: This study aimed to investigate the lipid-lowering effect of Red Glutinous Sorghum (RGS) in high-fat diet-induced obese mice. Mice were randomly divided into a normal control group (NC, n = 6, normal diet) and a high-fat diet group (HFD, n = 12, high-fat diet) and fed for 9 weeks to establish an obesity model. After successful model establishment, the HFD-fed mice were randomly reassigned to either the HFD group (n = 6, high-fat diet) or the RGS group (n = 6, RGS-diet) for a 7-week intervention period. Body weight, liver weight, and fat weight were recorded throughout the experiment. Hepatic pathological changes were observed using hematoxylin-eosin (HE) staining. Serum and hepatic levels of TG, TC, LDL-C, and HDL-C were measured. Western blot analysis was employed to assess protein expression levels of IL-6 and FASN in liver tissue. The results showed that, compared with the HFD group, RGS treatment significantly decreased body weight, liver index, fat index, and serum/hepatic levels of TG, TC, LDL-C (P P P