TITLE:
Passive EEG-Guided Neuromodulation in Chronic Migraine: Findings from a Prospective Feasibility Study with Three-Month Follow-Up Using the Neurogen Brain Balancing Migraine Protocol (NGBBMP)
AUTHORS:
Stefan J. Kasian, Rachel Turetzky, Douglas S. Wingate
KEYWORDS:
Chronic Migraine, Neuromodulation, EEG-Guided Neuromodulation, Low-Intensity Pulsed Transcranial Electrical Stimulation, Passive Brain Modulation, Neuroplasticity, Migraine Disability
JOURNAL NAME:
Health,
Vol.18 No.3,
March
31,
2026
ABSTRACT: Introduction: Chronic migraine is a highly disabling neurological condition characterized by recurrent attacks, sensory hypersensitivity, and substantial functional impairment. Many individuals experience incomplete relief from pharmacologic therapies and effort-dependent behavioral interventions. Neurogen Brain Balancing (NGBB) is a fully passive, EEG-guided neuromodulation approach utilizing ultra-low-intensity pulsed transcranial signaling designed to support network-level regulation. This prospective study evaluated feasibility, tolerability, and preliminary clinical response patterns associated with a brief NGBB protocol in treatment-experienced migraineurs. Methods: Twenty adults (19 female, 1 male; mean age 40.5 years) with a mean migraine history of approximately 14 years completed five standardized 30-minute NGBB sessions over four weeks. Outcomes included validated migraine disability and impact measures (MIDAS, HIT-6), pain intensity ratings, quality-of-life (QOL) interference scales, global effectiveness ratings, and qualitative reports. Participants were invited to complete a voluntary 90-day follow-up assessment. Analyses emphasized descriptive statistics, pre-/post-comparisons, effect size estimation, and exploratory follow-up distributions. Results: Baseline migraine burden was substantial (mean ≈ 13 migraine days/month; mean pain 7.85/10). Following treatment, participants demonstrated marked reductions in disability and headache impact. MIDAS scores declined from 77.7 (Severe Disability) to 16.5 (Moderate Disability), representing an approximate 79% reduction. HIT-6 scores decreased from 67.15 (“Very Severe Impact”) to 53.95 (“Some Impact”). Quality-of-life interference improved by approximately 49% across measured domains. Effect sizes were large across principal outcomes (MIDAS d = 4.61; HIT-6 d = 8.32; QOL d = 6.75). At voluntary 90-day follow-up (n = 9 respondents), the majority reported sustained reductions in migraine frequency (89%), intensity (78%), and painfulness (78%). Most respondents clustered within minimal headache burden ranges, and severe pain ratings were absent. No worsening symptom patterns or moderate/severe delayed adverse events were reported. Conclusions: In this feasibility study of individuals with long-standing, treatment-experienced migraine, a brief course of passive EEG-guided neuromodulation was associated with rapid, multidimensional reductions in disability and headache impact. Exploratory follow-up findings demonstrated a preliminary durability signal characterized by directional stability across symptom domains and attenuation of peak pain severity. These findings support further investigation in randomized, sham-controlled trials incorporating objective biomarkers and longer-term follow-up.