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Nottola, S.A., Coticchio, G., De Santis, L., Macchiarelli, G., Maione, M., Bianchi, S., et al. (2008) Ultrastructure of human mature oocytes after slow cooling cryopreservation with ethylene glycol. Reproductive BioMedicine Online, 17, 368-377. doi:10.1016/S1472-6483(10)60220-9

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• TITLE: Elective oocyte freezing for the preservation of fertility

  AUTHORS: Jason Barritt, Martha Luna, Benjamin Sandler, Marlena Duke, Alan B. Copperman

  KEYWORDS: Human Oocyte Cryopreservation; Fertility Preservation; Oocyte Aging; Ovarian Reserve; Follicle Stimulating Hormone; Basal Antral Follicle Count

  JOURNAL NAME: Open Journal of Obstetrics and Gynecology, Vol.2 No.1, March 31, 2012

  ABSTRACT: Oocyte cryopreservation has recently emerged as an option for women to preserve their fertility for medical (e.g. treatable malignancy) or elective indications (e.g. advancing age). This report describes an IRB-approved study of over 200 oocyte cryopreservation cycles at one center. Patients presenting for oocyte cryopreservation (January 2005 to 2010) were analyzed for day 3 follicle stimulating hormone (FSH), basal antral follicle count (BAFC), gonadotropin usage and the number of oocytes retrieved and cryopreserved. New patient consultations were performed on 516 women, of whom 175 (34%) proceeded to initiate a total of 233 cryopreservation cycles. Twenty-four cycles were cancelled (10%) after starting follicular stimulation due to poor ovarian response or self-withdrawal of the patients. Patients whose cycles were cancelled demonstrated a higher Day 3 FSH and a lower BAFC than patients who completed cycles (p