Article citationsMore>>

Zeng, Q., Liu, J., Mu, J., Yang, J., Gao, Q., Wu, F., et al. (2023) Optimal Biopsy Site for the Diagnosis of Oral Pemphigus Vulgaris and Mucous Membrane Pemphigoid: A Systematic Review and Meta-Analysis. International Journal of Oral and Maxillofacial Surgery, 52, 1162-1172.
https://doi.org/10.1016/j.ijom.2023.05.005

has been cited by the following article:

• TITLE: When the Mouth Speaks First: Isolated Oral Pemphigus Vulgaris—A Case Report and Literature Review

  AUTHORS: Salma Azizi Alaoui, Wafaa Mahfoud, Kaoutar El Khalifa, Lamia Kissi

  KEYWORDS: Pemphigus Vulgaris, Mouth Mucosa, Stomatitis, Autoimmune Diseases, Corticosteroids, Acantholysis, Immunofluorescence, Tooth Extraction

  JOURNAL NAME: Open Access Library Journal, Vol.13 No.3, March 18, 2026

  ABSTRACT: Background: Pemphigus vulgaris (PV) is a rare autoimmune blistering disease in which oral lesions often precede cutaneous involvement. Early diagnosis may be delayed because of nonspecific presentations. Case Presentation: A 28-year-old woman presented with a one-year history of painful oral bullae and erosions without skin lesions. Clinical examination revealed multifocal erosions and a positive Nikolsky’s sign. Histopathology demonstrated suprabasal clefting, acantholysis, and a “tombstone” basal layer, confirming PV. Systemic prednisone (60 mg/day) resulted in significant improvement within 10 days. Persistent inflammation related to impacted mandibular third molars was addressed surgically. By day 40, oral lesions had fully resolved; however, new-onset dysphagia raised concern for pharyngeal or esophageal involvement, necessitating referral to internal medicine. Conclusion: This case underscores the importance of early biopsy, recognition of local inflammatory triggers, and coordinated multidisciplinary care in isolated oral PV to prevent disease progression.