TITLE:
Hyperthyroidism during Pregnancy: Clinical and Paraclinical Features and Maternal-Fetal Outcomes
AUTHORS:
Sokhna Awa Balla Sall, Ngoné Diaba Diack, Khadim Mbaye, Simon Birame Ndour, Zineb Ouazzani, Mamadou Ba, Abdou Karim Diallo, Nafy Ndiaye, Mohamed Yakham Leye, Alassane Mbaye, Abdoul Aziz Diouf, Abdoulaye Leye
KEYWORDS:
Hyperthyroidism, Pregnancy, Fetal, Etiology, Complications
JOURNAL NAME:
Open Journal of Endocrine and Metabolic Diseases,
Vol.16 No.3,
March
17,
2026
ABSTRACT: Introduction: During pregnancy, changes cause physiological hyperfunction of the thyroid gland. In some cases, this thyroid hyperfunction can be pathological. Therefore, we aimed to determine the clinical and biological aspects, and maternal-fetal complications of this condition in a Dakar hospital setting. Methodology: We conducted a prospective and retrospective descriptive study for analytical purposes covering the period from January 1, 2018, to June 30, 2023, in the Endocrinology-Diabetology-Nutrition Department of the Pikine National Hospital Center. All patients monitored for hyperthyroidism during pregnancy during this period were included. Results: Forty patients were included. The prevalence of pregnancy among women followed for hyperthyroidism was 2%. The average age was 29.63 years. Most patients had thyrotoxicosis syndrome and goiter. Acquired exophthalmos was present in 45% of patients. The mean T4L was 39.19 pmol/L. The most common etiology was Graves’ disease. Benzylthiouracil was the most commonly prescribed ATS. The mean gestational age at the first endocrinology consultation was 14 weeks. Obstetric pathologies were found in 52.5% of patients. The most common route of delivery was vaginal. Subsequently, three patients underwent total thyroidectomy. Conclusion: Severity is associated with a higher risk of complications. Multidisciplinary collaboration and appropriate follow-up are essential as they determine the prognosis.