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Thiel, K.-D., Wutzler, P., Helbig, B., Klockning, R., Sprossig, M. and Schweizer, H. (1984) Antivirale Wirksamkeit von enzymatisch und nicht-enzymatisch oxidierter Kaffee- und Hydrokaffeesaure gegenüber Herpesvirus hominis Typ 1 und Typ 2 in vitro. Pharmazie, 39, 781-782.

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• TITLE: Efficacy and tolerability of propolis special extract gh 2002 as a lip balm against herpes labialis: a randomized, double-blind three-arm dose finding study

  AUTHORS: Simona Holcová, Marie Hladiková

  KEYWORDS: Herpes labialis; propolis; lip balm; dose-finding study

  JOURNAL NAME: Health, Vol.3 No.1, January 30, 2011

  ABSTRACT: A dose-finding study was performed with respect to the clinical applicability and tolerability of three different concentrations of propolis special extract GH 2002 in a lip balm (0.1%, 0.5% and 1%). The trial was designed as a double-blind, randomized dermatological study in 150 outpatients with Herpes labialis. The primary parameter was the duration in days until painless incrustation in 50% or 90% of the patients (observable in 121 patients). Secondary parameters were local pain (assessed on a visual analogue scale), itching, burning and tension/ swelling on a verbal rating scale, and tolerability. Visits were performed on days 2/3, 5/6 and 8/9. Best efficacy results with shortest healing time (3.4 and 5.4 days in the 50th and 90th percentile, respectively; p = 0.008 vs. 1% and 0.09 vs. 0.1%) and good tolerability were observed with the 0.5% concentration. All three concentrations achieved highly significant therapeutic results in comparison with baseline values (p