TITLE:
Efficacy and Safety of Intra-Arterial Infusion Chemotherapy Combined with Early Radiotherapy for Bulky Cervical Cancer
AUTHORS:
Dahe Zhan, Wangti Xie
KEYWORDS:
Intra-Arterial Infusion Chemotherapy, Intracavitary Afterloading Brachytherapy, Bulky Cervical Cancer
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.14 No.3,
March
12,
2026
ABSTRACT: Background: This study aimed to observe the efficacy and safety of early radiotherapy combined with intra-arterial infusion chemotherapy (IACT) for bulky cervical cancer. Methods: A total of 20 patients with locally advanced bulky cervical cancer admitted to Yueyang Central Hospital from January 2018 to January 2022 were enrolled. All patients received IACT combined with early radiotherapy (including intracavitary afterloading brachytherapy and external beam radiotherapy). Intracavitary afterloading brachytherapy was performed early after infusion chemotherapy, and external beam radiotherapy was initiated within 2 weeks. Clinical efficacy was evaluated using MRI or CT, and the therapeutic efficacy and adverse reactions were analyzed. Results: Among the 20 patients, the overall response rate (ORR) was 100%. Significant necrosis and shedding were observed in 95% of patients after the second brachytherapy session. By the third afterloading treatment, 95% of patients achieved partial response (PR), and 90% achieved complete response (CR) after the entire treatment course. No severe adverse reactions affecting treatment were reported in any patient. Conclusion: The combination of radiotherapy within a short period after interventional infusion chemotherapy can significantly improve the short-term efficacy of bulky cervical cancer with good safety.