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H. Shu, B. Wong, G. Zhou, Y. Li, J. Berger, J. W. Woods, S. D. Wright and T. Q. Cai, “Activation of PPAR Alpha or Gamma Reduces Secretion of Matrix Metalloproteinase 9 but Not Interleukin 8 from Human Monocytic THP-1 Cells,” Biochemical and Biophysical Research Communications, Vol. 267, No. 1, 2000, pp. 345-349. doi:10.1006/bbrc.1999.1968

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• TITLE: Effects of Walnut on Lipid Profile as Well as the Expression of Sterol-Regulatory Element Binding Protein-1c(SREBP-1c) and Peroxisome Proliferator Activated Receptors α (PPARα) in Diabetic Rat

  AUTHORS: Ebrahim Abbasi Oshaghi, Arash Noori Sorkhani, Ali Rezaei

  KEYWORDS: Walnut; Cholesterol; SREBP-1c; PPARα

  JOURNAL NAME: Food and Nutrition Sciences, Vol.3 No.2, February 27, 2012

  ABSTRACT: Diabetes Mellitus has appeared as a universal burden. Studies have reported that mortality from Coronary Heart Disease (CHD) in diabetic patients is 2 - 4 times higher than nondiabetics. In this respect, walnut is a treatment which has beneficial effects on CHD risk factors. PPARα and SREBP-1c play an important role in the regulation of lipid metabolism. This study was aimed to evaluate the effects of walnut on lipid profile as well as SREBP-1c and PPARα protein levels in rats. Animals were randomly divided into 3 groups (n = 6); Group 1: Received chow only (control), Group 2: Diabetic rats + chow, Group 3: Diabetic rats + chow supplemented with 4% of whole walnuts. After four weeks rats were sacrificed, blood was collected; lipid profiles as well as SREBP-1c and PPARα protein levels were determined. Compared with diabetic rats walnut significantly decreased serum cholesterol (P