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M. A. Montanaro, A. M. Bernasconi, M. S. Gonzalez, O. J. Rimoldi and R. R. Brenner, “Effects of Feno?brate and Insulin on the Biosynthesis of Unsaturated Fatty Acids in Streptozotocin Diabetic Rats,” Prostaglandins, Leukotrienes and Essential Fatty Acids, Vol. 73, No. 5, 2005, pp. 369-378. doi:10.1016/j.plefa.2005.06.004

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• TITLE: Effects of Walnut on Lipid Profile as Well as the Expression of Sterol-Regulatory Element Binding Protein-1c(SREBP-1c) and Peroxisome Proliferator Activated Receptors α (PPARα) in Diabetic Rat

  AUTHORS: Ebrahim Abbasi Oshaghi, Arash Noori Sorkhani, Ali Rezaei

  KEYWORDS: Walnut; Cholesterol; SREBP-1c; PPARα

  JOURNAL NAME: Food and Nutrition Sciences, Vol.3 No.2, February 27, 2012

  ABSTRACT: Diabetes Mellitus has appeared as a universal burden. Studies have reported that mortality from Coronary Heart Disease (CHD) in diabetic patients is 2 - 4 times higher than nondiabetics. In this respect, walnut is a treatment which has beneficial effects on CHD risk factors. PPARα and SREBP-1c play an important role in the regulation of lipid metabolism. This study was aimed to evaluate the effects of walnut on lipid profile as well as SREBP-1c and PPARα protein levels in rats. Animals were randomly divided into 3 groups (n = 6); Group 1: Received chow only (control), Group 2: Diabetic rats + chow, Group 3: Diabetic rats + chow supplemented with 4% of whole walnuts. After four weeks rats were sacrificed, blood was collected; lipid profiles as well as SREBP-1c and PPARα protein levels were determined. Compared with diabetic rats walnut significantly decreased serum cholesterol (P