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Yoshida, A., Ushiku, T., Motoi, T., Shibata, T., Beppu, Y., Fukayama, M., et al. (2010) Immunohistochemical Analysis of MDM2 and CDK4 Distinguishes Low-Grade Osteosarcoma from Benign Mimics. Modern Pathology, 23, 1279-1288.
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has been cited by the following article:

• TITLE: CT and MRI Findings of Epithelioid Hemangioma of Bone: A Case Report

  AUTHORS: Miaoyin Chen, Liangping Luo

  KEYWORDS: Epithelioid Hemangioma, Bone Tumor, Misdiagnosis, Imaging Diagnosis and Differential Diagnosis

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.14 No.3, March 9, 2026

  ABSTRACT: Epithelioid hemangioma (EH) of bone is a rare, locally aggressive vascular tumor, classified as an intermediate-grade neoplasm in the WHO classification. This article reports a case of a 15-year-old male patient presenting with left knee pain for over one month. Imaging revealed a well-defined osteolytic lesion in the left tibial metaphysis without a sclerotic border or periosteal reaction. MRI showed the lesion to be markedly hyperintense on T2WI, with progressive heterogeneous enhancement post-contrast. Histopathological examination confirmed epithelioid endothelial cell proliferation, supported by a characteristic immunohistochemical profile (CD31+, ERG+), leading to a diagnosis of EH. This case highlights the atypical presentation of EH in an adolescent and emphasizes the role of multimodal imaging and histopathological correlation in diagnosis.