TITLE:
CT and MRI Findings of Epithelioid Hemangioma of Bone: A Case Report
AUTHORS:
Miaoyin Chen, Liangping Luo
KEYWORDS:
Epithelioid Hemangioma, Bone Tumor, Misdiagnosis, Imaging Diagnosis and Differential Diagnosis
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.14 No.3,
March
9,
2026
ABSTRACT: Epithelioid hemangioma (EH) of bone is a rare, locally aggressive vascular tumor, classified as an intermediate-grade neoplasm in the WHO classification. This article reports a case of a 15-year-old male patient presenting with left knee pain for over one month. Imaging revealed a well-defined osteolytic lesion in the left tibial metaphysis without a sclerotic border or periosteal reaction. MRI showed the lesion to be markedly hyperintense on T2WI, with progressive heterogeneous enhancement post-contrast. Histopathological examination confirmed epithelioid endothelial cell proliferation, supported by a characteristic immunohistochemical profile (CD31+, ERG+), leading to a diagnosis of EH. This case highlights the atypical presentation of EH in an adolescent and emphasizes the role of multimodal imaging and histopathological correlation in diagnosis.