TITLE:
Multiple Ischemic Strokes Associated with Pulmonary Embolism Revealing Occult Pulmonary Adenocarcinoma: About Two (2) Cases and Review of the Literature
AUTHORS:
Camara Mamady, Diallo Mohamed Tafsir, Toure Laila, Sacko Aboubacar Sidiki, Camara Baky Dominique Batoumbla, Camara Idrissa Aissatou, Camara Alpha, Konate Ibrahima Sory, Toure Fatoumata, Toure Mohamed Lamine, Barry Souleymane Djigué, Cisse Fodé Abass
KEYWORDS:
Multiple Stroke, Pulmonary Embolism, Adenocarcinoma
JOURNAL NAME:
Voice of the Publisher,
Vol.12 No.1,
March
5,
2026
ABSTRACT: A rare clinical phenomenon has been reported. Patients with pulmonary adenocarcinoma consulted the neurology department due to multiple initial symptoms of cerebral ischaemia. Examination of each patient revealed pulmonary embolism, the underlying cause being a malignant lung tumour. Multiple ischaemic strokes (IS) associated with pulmonary embolism (PE) rarely indicate pulmonary adenocarcinoma. The concomitant presence of IS, PE and pulmonary adenocarcinoma increases the risk of complications and mortality. We report two (2) cases of diagnostic cascades marked by the discovery of multiple ischaemic strokes, followed by pulmonary embolisms and finally lung adenocarcinoma. Our patients, aged 58 and 55, were both smokers. Initially, the patients presented with focal neurological deficits symptomatic of multiple ischaemic strokes. The aetiological assessment revealed a state of hypercoagulability, which led to the discovery of pulmonary embolisms and lung adenocarcinoma. In terms of treatment, all of our patients received antiplatelet therapy and low molecular weight heparin. The outcome was marked by recurrent ischaemic strokes followed by the death of the patients from general complications.