TITLE:
Merkel Cell Carcinoma: Diagnostic and Therapeutic Challenges—A Case Report with Literature Review
AUTHORS:
Chaymae Chbihi, Zaid Ennasery, Samia El Hakym, Hafssa El Hilali, Abir Oufrid, Sara Nejjari, Diango Keita, Serge Kumbi, Oumaima Siyouri, Nawal Hammas, Lamiae Amaadour, Karima Oualla, Zineb Benbrahim, Samia Arifi, Nawfel Mellas
KEYWORDS:
Merkel Cell Carcinoma, Neuroendocrine Tumor, Gluteal Region, Chemotherapy, Resource-Limited Settings, Immunotherapy
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.17 No.3,
March
2,
2026
ABSTRACT: Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous neuroendocrine tumor predominantly affecting elderly and immunocompromised patients. It is characterized by a high propensity for local recurrence, regional lymph node involvement, and distant metastasis, leading to poor outcomes. Diagnosis remains challenging due to its rarity and nonspecific presentation, often leading to misdiagnosis. We report a case of locally advanced MCC originating in the gluteal region, exhibiting aggressive behavior. In the Moroccan context, where access to immunotherapy is limited, the patient was managed with chemotherapy, achieving transient disease control within a multimodal treatment strategy. This case report is accompanied by a literature review to discuss current therapeutic strategies and to underscore the challenges in managing MCC in resource-limited settings.