TITLE:
Successful Controlled Ovarian Stimulation and Livebirth in a Patient with MoyaMoya Disease: A Case Report
AUTHORS:
Kerri Spontarelli Fruit, Steven Nicholas Cochran, Hannah McCool, Samuel Prien, Khaliq Ahmad, Lindsay Penrose, Bo Young Suh
KEYWORDS:
MoyaMoya Disease (MMD), Ovarian Stimulation, In Vitro Fertilization, Assisted Reproductive Technologies, Thrombosis
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.16 No.2,
February
14,
2026
ABSTRACT: The cerebrovascular disorder, MoyaMoya disease (MMD), increases the risk of ischemic stroke due to stenosis of the cerebral vasculature. Progressive occlusion leads to the development of weak collateral vessels, which can cause hemorrhagic stroke. Controlled ovarian stimulation for procreation by assisted reproductive technologies induces supraphysiologic serum estrogen levels up to 100 times or greater above baseline values and has been shown to increase the risk of venous thrombosis, making assisted reproduction a unique challenge in patients with MMD. This case report describes a controlled ovarian stimulation and subsequent livebirth in a patient with MMD as well as Factor V Leiden, a thrombophilia that predisposes patients to venous thrombosis.